Expression of alpha-smooth muscle actin in liver diseases

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Expression of alpha-smooth muscle actin in liver diseases.

To evaluate the distribution of alpha-smooth muscle actin (alpha-SMA) positive cells in various liver diseases, we undertook an immunohistochemical study of liver diseases including chronic persistent hepatitis, chronic active hepatitis, liver cirrhosis, intrahepatic cholelithiasis and hepatocellular carcinoma. As a control, fetal livers (gestational age: 22-26 weeks) showed alpha-SMA positive ...

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PURPOSE Lens epithelial cells transdifferentiate to myofibroblasts during the formation of anterior subcapsular cataracts and secondary cataracts. One of the defining characteristics of myofibroblasts is the expression of alpha-smooth muscle actin (alpha-SMA). This study investigated some of the factors that influence alpha-SMA expression in lens epithelial cells. METHODS Bovine, rabbit, and ...

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Expression of alpha smooth muscle actin in living donor liver transplant recipients.

Recently, there have been reports from liver biopsies that showed the progression of liver fibrosis in liver transplant patients after the cessation of immunosuppression. Herein, we focused on activated hepatic stellate cells expressing alpha smooth muscle actin (α-SMA) to understand the correlation between immunosuppressant medication and liver fibrosis. The study enrolled two pediatric patien...

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Alpha-smooth muscle actin expression upregulates fibroblast contractile activity.

To evaluate whether alpha-smooth muscle actin (alpha-SMA) plays a role in fibroblast contractility, we first compared the contractile activity of rat subcutaneous fibroblasts (SCFs), expressing low levels of alpha-SMA, with that of lung fibroblasts (LFs), expressing high levels of alpha-SMA, with the use of silicone substrates of different stiffness degrees. On medium stiffness substrates the p...

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induction of thymic hla-dr signaling with alpha-smooth muscle actin expression during the second and third trimesters of gestation

less than 5% of prenatal thymoctes express hla-dr before week 12 of gestation. however, the number of hla-dr- positive cells increases during the late second and third trimesters of development. to determine the role of alpha-smooth muscle actin in fetal thymic hla-dr signaling in different stages of development we examined and compared the immunohistochemical expression of alpha-smooth muscle ...

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ژورنال

عنوان ژورنال: Journal of Korean Medical Science

سال: 1993

ISSN: 1011-8934,1598-6357

DOI: 10.3346/jkms.1993.8.5.367